Here we show a relationship between EMT, Nrf2, and metabolic reprogramming, using stable isotope carbon tracing based GC/MS, LC-MS/MS, and RNAseq in isogenic non-small cell lung cancer (NSCLC) adenocarcinoma models of epithelial and mesenchymal-like states. This evidence concerns the gene NFE2L2 and non-small cell lung carcinoma.