CD274 and neoplasm: Accumulating evidences showed that exosomes from HL and EBV-positive HL exacerbate the worse phenotype of the tumor by remodeling the tumor microenvironment by carrying several important molecules (i.e., VEGF, LMP1, PD-L1), whose circulating concentration positively correlate with IFN-γ concentration and T-cell function (Figure 3).