Thus by inducing changes in effector immune cells and blood vessel permeability and architecture, these alterations contribute to recruit immunosuppressive cells and blocking tumor-reactive T-cells [44]; alterations in Wnt/β-catenin signaling causes a decrease in the production of the chemoattractant chemokine CCL4, which leads to a decreased infiltration of natural killer and dendritic cells in the tumor microenvironment [45]. This evidence concerns the gene CCL4 and neoplasm.