The HRS malignant cell in cHL shows a high expression of PD-L1/PD-L2 due to a particularly high frequency of PDL1/PDL2/JAK2 genetic alterations [23] and a correlation with EBV-positive status, mediated by LMP1 (Figure 2) [24]. Here, PDCD1LG2 is linked to classic Hodgkin lymphoma.