SCN1A and Dravet syndrome: In this frame, Hsiao and colleagues [42] upregulated specifically SCN1A expression in a DS mouse model by using AntagoNATs (oligonucleotide-like compounds) blocking SCN1ANAT, while not altering >90% of all of the expressed genes, including other highly homologous sodium channel subunits and genes that are immediately adjacent to SCN1A on the chromosome [42].