The univariate regression analysis showed a significant association of advanced age (p < 0.001, OR (95%CI) 1.052 (1.042–1.061)), increased CRP (p < 0.001, OR (95%CI) 1.015 (1.011–1.018)), male sex (p < 0.001, OR (95%CI) 1.4 (1.164–1.684)), and the presence of diabetes (p < 0.001, OR (95%CI) 2.723 (2.250–3.296)) with the occurrence of CLTI. Here, CRP is linked to diabetes mellitus.