SOD1 and amyotrophic lateral sclerosis: Moreover, unique proinflammatory miRNA and gene profiles were found in the blood of patients with ALS and in the microglia of mutant SOD1 mice, including increased expressions of miR-27a, miR-155, miR-146a, miR-451, miR-223, miR-142-5p, let-7a/b, and miR-532-3p, and a reduced expression of transforming growth factor beta 1 (TGF-β1) [55].