Although we observed AMPK deactivation in the livers of EtOH-fed mice of both strains, a decreased blood EtOH clearance as observed only in ADH− deer mice fed 3.5% EtOH suggest an inhibition of lipophagy/degradation of LDs leading to steatosis and hepatic lipid accumulation in our model. The gene discussed is AVP; the disease is steatosis.