BRD4 and acute myeloid leukemia: Some works have reported these kind of adaptive response in AML cells, in which the acquisition of resistance to BET inhibitors has been linked to a downmodulation of BRD4 protein and activation of the NF-κB pathway without altering the expression levels of MYC, coinciding with an aberrant activation of the WNT/β-catenin and the TGF-β signaling pathways [101].