Recently, BRD4 has also been described as an important regulator of AML cell autophagy through distinct complementary mechanisms including (i) a direct modulation of autophagy-related genes, and (ii) an indirect increase of reactive oxygen species release by KEAP1 (kelch like ECH associated protein 1), followed by a blockade of the NRF2 (nuclear factor, erythroid 2 like 2) antioxidant pathway [55]. Here, KEAP1 is linked to acute myeloid leukemia.