CCND1 and mantle cell lymphoma: These findings are particularly relevant in MCL, as this entity is characterized by the t(11;14) translocation that fuses the CCND1 gene, coding for cyclin D1, to the immunoglobulin heavy locus gene, leading to the overexpression of the cyclin, thus increasing CDK4/6 activity with the consequent deregulation of the cell cycle at the G1 to S transition [51].