The study from Zeng et al. showed the that CPEB4 may function as a tumor suppressor in head and neck squamous cell carcinoma, and hypermethylation of the CPEB4 gene accountable for the downregulation of CPEB4 expression lead to tumorigenesis of head and neck squamous cell carcinoma [43]. The gene discussed is CPEB4; the disease is head and neck squamous cell carcinoma.