Gene ontology and network analysis of differentially expressed genes common in LNCaP and C4-2B for long-term effects of curcumin only showed 3 up-regulated genes: Ferritin Heavy Chain 1 (FTH1), Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4), and C6orf61, the Minichromosome Maintenance 9 Homologous Recombination Repair Factor (MCM9) and one down-regulated gene PMEPA1. These genes are known to be regulators of the cancer phenotype. This evidence concerns the gene CPEB4 and cancer.