The analysis further identified 3 down-regulated central nodes, including RAF1 (Raf-1 Proto-Oncogene, Serine/Threonine Kinase), BCL6 (B-Cell CLL/Lymphoma 6), IGF1R (Insulin-Like Growth Factor 1 Receptor), as well as 5 up-regulated central nodes such as PTEN (Phosphatase And Tensin Homolog), EGFR1 (Epidermal Growth Factor Receptor 1), SMAD7 (SMAD Family Member 7), FOXO3 (Forkhead Box O3), AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1) and RAD51 (RAD51 Recombinase). The gene discussed is FOXO3; the disease is B-cell chronic lymphocytic leukemia.