INS and obesity due to melanocortin 4 receptor deficiency: Indeed, a recent study showed that treatment with HA nanoparticles in diet-induced obesity mice suppressed adipose tissue inflammation as indicated by reduced macrophage content, the production of proinflammatory cytokines and NLRP3 inflammasome activity in epididymal white adipose tissue (WAT), leading to improved insulin sensitivity and normalized blood glucose levels [30].