ACE and heart failure: Moreover, the Prospective Comparison of Sacubitril/Valsartan with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) study showed a significant improvement of left ventricular ejection fraction (LVEF) in patients suffering from heart failure with reduced ejection fraction (HFrEF) as compared to angiotensin converting enzyme inhibitors [2].