AndosanTM is a Japanese extract of 82% AbM, 15% H. erinaceus, and 3% G. frondosa that gave anti-allergic effects in a mouse allergy model, as demonstrated by reduced serum IgE and IgG1 anti-ovalbumin levels and shift from Th2 to Th1 predominant cytokine profiles in spleen cell cultures [10]. Here, IGHE is linked to allergic disease.