We examined whether the AbM-based mushroom extract AndosanTM, taken orally before the pollen season, could reduce allergy and asthma symptoms, medication, and specific IgE basophil sensitization to t3 (birch pollen extract) and Bet v 1 (major component from birch) and could influence the Th1/Th2 cytokine balance in otherwise healthy humans as found in mouse models for allergy and asthma [9,10]. This evidence concerns the gene NELFCD and allergic disease.