The current selected blood donors with self-reported pollen allergy and specific IgE-verified sensitization (placebo group examined) had significantly higher IgE anti-t3 levels than 100 unselected donors (median 10.2 vs. 0.0 kU/L, respectively; p < 0.001) that were examined the previous pollen season (mid-April 2015). Here, IGHE is linked to seasonal allergic rhinitis.