However, since it is known that most cases of MS may depend on the combined action of T cells and B cells [24], the possibility cannot be excluded that deregulation of MIF (and likely DDT) production and signaling may occur simultaneously and in an opposite fashion on CD4+ T cells and B cells, with the former being characterized by augmented production of MIF and the latter by a reduced production of MIF. Here, CD4 is linked to myeloid sarcoma.