In agreement with emerging literature, data on the role of MIF in immunoinflammatory demyelinating diseases these data warrant future studies aimed at deciphering the potential role of MIF cytokine family in CIS and the eventual predictivity of conversion to CDMS in patients with CIS that are high producers of MIF and DDT or bear specific MIF genetic polymorphisms. The gene discussed is MIF; the disease is in situ carcinoma.