In fact, while several studies have well documented the pathogenetic role of upregulated Th1 and Th17 mediated events in the development and progression of MS [29] much less is known on the role of Th subsets and their cytokines in the pathogenesis of CIS although a reduced levels of the anti-inflammatory cytokines IL-10 and TGF-beta has been reported to be associated with the disease [30,31]. Here, IL10 is linked to in situ carcinoma.