CXCR4 and in situ carcinoma: However, increased levels of MIF during CIS were not reported in a recent study [21] reporting that CIS patients experiencing a very rapid onset of CDMS had a 1.5-fold increased CXCR4 and 1.3-fold reduced CD74 surface levels as compared to those with slow or no onset of CDMS, pointing out to a negative correlation between CXCR4 and CD74 levels on B cells in these patients.