So far, several targets related to the central nervous system (CNS) like 5HT2C, NPY (NeuropeptideY), and AgRP (Agouti-related protein) etc., and the non-central nervous system like pancreatic lipase, leptin, ghrelin etc., [4,5] were reported as obesity targets. The gene discussed is AGRP; the disease is obesity due to melanocortin 4 receptor deficiency.