Similarly, treatment with a combination of MEK and AKT inhibitors in human non-small-cell lung cancer was found to be more effective than treatment with each drug alone [32], and pre-treatment with propranolol before chemotherapy, such as 5-fluorouracil or paclitaxel, may increase relapse-free and overall survival in breast cancer patients [33]. This evidence concerns the gene AKT1 and breast carcinoma.