Concurrence of pathogenic mutations in melanoma driver genes was observed in a fraction of cases from our series (six out of 25 patients, 24%, Figure 1), while single nucleotide polymorphisms in KDR, CCND1, CDKN2A, and TP53 genes, and non-synonymous variances of unknown functional significance (VUS) largely occurred in the tissue samples (23/25, 92%) (Figure 1). The gene discussed is KDR; the disease is melanoma.