Recently, a more extensive catalogue of driver mutations in sinonasal mucosal melanomas has been reported [23,24,25], either confirming the involvement of both the MAPK and the PI3K-Akt pathways or suggesting a role for additional candidate genes (NF1, SF3B1, TP53, SPRED1, ATRX HLA-A, and CHD8). This evidence concerns the gene TP53 and melanoma.