BRAF and neoplasm: Whereas BRAF (or RAS) expression in premalignant melanocytic nevi leads to OIS–which is characterized by cell-cycle arrest and an impediment of tumor formation–the overexpression of JMJD2C or LSD1 in BRAF-mutated cells promotes melanomagenesis by overcoming the dynamic phenotypic state enabled by BRAF-induced senescence.