The most used parameters to characterize this preclinical model include: clinical signs and symptoms (body weight, stool consistency, and morbidity), concentration of inflammatory biomarkers (IFN-γ, MPO, TNF-α, IL-6, and IL-10), macroscopic evaluation of the colon (ulcers, thickness, and hyperemia) and histological evaluation of the colon. This evidence concerns the gene IL6 and ulcer disease.