LPS could activate toll-like receptor 4 (TLR4) in hepatocytes and kupffer cells [11], and then induce the phosphorylation of nuclear factor-κB (NF-κB) and the secretions of the pro-inflammatory cytokines such as IL-6, TNF-α, and IL-1β, thereby exacerbate liver inflammation injury [12]. The gene discussed is TLR4; the disease is Hepatitis.