NOS2 and asthma: HPOX NPs were designed to integrate the anti-oxidant and anti-inflammatory properties of HBA and the peroxalate ester linkage’s ability to react to H2O2 and they showed an ability to suppress the expression of pro-inflammatory mediators such as inducible nitric oxide synthase (iNOS) and interleukin (IL)-4 in a murine model of asthma.