31–43 peptide rapidly increased the number of IL-15+ cells in the lamina propria of CeD in-vitro organ cultures and consequently promoted the expression of COX-2, CD25 in lamina propria mononuclear cells and CD83 on dendritic cells, indicating its capability to activate the innate immune system in celiac patients [69]. The gene discussed is IL15; the disease is cranioectodermal dysplasia.