VTCN1 and non-small cell lung carcinoma: Despite the fact that the clinical meaning of B7-H4 in NSCLC has been debated for many years, a recent meta-analysis comprising nine studies, for a total of 1444 patients with NSCLC at any stage, demonstrated a correlation between B7-H4 expression and clinicopathological features such as poor differentiation, advanced disease stage, and poor survival, suggesting a prognostic role of this biomarker [21].