As an example, Hegazy et al. [27], have shown that the administration of Lactobacillus delbrueckii and Lactobacillus fermentum to ulcerative colitis patients decreased the recruitment of leukocytes to the colonic mucosa and the expression levels of different colonic inflammatory cytokines such as IL-6, TNF-α, or NF-κB p65. This evidence concerns the gene TNF and ulcerative colitis.