This study shows that TXA given prior to trauma in a manner similar to use in a semi-elective surgery can delay the development of coagulopathy as measured by PT, reduce systemic fibrinolysis as measured by D-dimer, and decrease fibrinolytic potential in injured tissue as measured by plasmin(ogen) and fibrin(ogen) distribution at injured site of tissue. This evidence concerns the gene PLG and blood coagulation disease.