TNF and focal segmental glomerulosclerosis: Additionally, results from the FONT study [17, 18] suggest that only a subset of patients with FSGS responds to TNF inhibition and Mariani et al. (2018) reported that only patients at high risk for FSGS progression (cluster 3 patients) are characterized by a transcriptional profile consistent with TNF activation that correlates with eGFR loss [21].