In the FLAURA study [15] comparing first-line osimertinib with gefitinib or erlotinib in patients with advanced EGFR-mutated NSCLC, the median PFS (mPFS) was significantly longer with osimertinib than with standard F-TKIs (18.9 versus 10.0 months, P < 0.001). Here, EGFR is linked to non-small cell lung carcinoma.