EGFR and non-small cell lung carcinoma: However, in another phase III trial [13–14] comparing dacomitinib with gefitinib in patients with EGFR-mutated NSCLC without brain metastases, dacomitinib was associated with significant improvement in mPFS (14.7 versus 9.2 months, P < 0.001) and mOS (34.1 months versus 26.8 months, P = 0.044) compared with gefitinib, but with increased grade 3 toxicities.