The increase in RPL22L1 expression is causally linked to RPL22 loss, because knockdown of Rpl22 in the mouse intestinal epithelial cell line ModeK (Fig 1B) and the CRC cell line HCT116 (Fig 1C), using two different hairpins, was sufficient to substantially increase RPL22L1 expression, suggesting that RPL22 negatively regulates Rpl22L1. The gene discussed is RPL22; the disease is colorectal carcinoma.