These results are in agreement with the findings of Corken et al. [39], who demonstrated that the loss of a single platelet receptor, GPIb-IX, was sufficient to increase the level of neutrophil Mac-1 (CD11b/CD18) expression that occurs 24 hours post onset of sepsis in a mouse model of polymicrobial sepsis. The gene discussed is ITGB2; the disease is Sepsis.