Following the observation that concomitant DNA-PK inhibition and systemic chemotherapy may have a narrow therapeutic index, we sought to examine oral NU5455 treatment in combination with localized chemotherapy, and selected doxorubicin-loaded DC M1 polymer beads (70–150 μm), which are used clinically in the treatment of HCC to deliver transarterial chemoembolization (34). The gene discussed is PRKDC; the disease is hepatocellular carcinoma.