While KCNK17 channels expressed in human heart atrial tissue [36] represent potential therapeutic targets to treat atrial and ventricular arrhythmias [37], to the best of our knowledge, our study is the first to report dysregulated expression of KCNK15 and KCNK17 mRNA and protein in HCC tissues. Here, KCNK17 is linked to hepatocellular carcinoma.