In the case of SW620 cells, a CRC‐derived cell line harboring G12V mutation in K‐Ras gene, it was also observed that the TNFα‐induced expressions of COX‐2, A20, and ICAM1 were not affected by the knockdown of MSK1/2 (Fig. S4). Here, RPS6KA5 is linked to colorectal carcinoma.