BRCA2 and breast cancer: BRCA1/BRCA2 carriers have a 17% to 44% risk of developing OC and 69% to 72% risk of BC to 80 years of age.10PALB2 (OMIM 610355) is a recently established high-penetrance BC gene associated with a 44% BC risk.11 A number of risk management options are available for unaffected relatives with pathogenic variants.