NR3C2 and hypothyroidism: This result is in agreement with a previous cross‐sectional study by Asmah, B. J. et al., who concluded that the basal plasma aldosterone concentration was not significantly different in either hypothyroidism or hyperthyroidism.49 Giving eplerenone to hypothyroid rats did not significantly change the aldosterone concentration, because the synthesis and release of aldosterone in the adrenal cortex are not affected by an aldosterone receptor blocker such as eplerenone.