This change might be due to hypotension triggered by the stimulation of intrarenal baroreceptors, which consequently stimulates renin release as a compensatory mechanism.46 The serum levels of angiotensin I and II were decreased significantly in rats with hypothyroidism, possibly because of a reduction of the serum renin concentration caused by thyroid dysfunction.47, 48. The gene discussed is AGT; the disease is hypothyroidism.