TARDBP and amyotrophic lateral sclerosis: To determine whether AMPAR subunit dysregulation is associated with upper and lower motor neurons or, non‐motor neurons in other brain regions also affected by TDP‐43 pathology in ALS patients we examined AMPAR subunit expression in the post‐mortem prefrontal cortex (BA9) of sALS, C9orf72RE and SOD1 I114T patients (Figure 5A).