THBS2 and fibrosis: Table 4 lists the predicted targets as well as the cellular toxicity pathway, for example, cell death, cardiac fibrosis, p53, and TGFβ signaling. Notably, DICER1, TGFB2, HDAC1, THBS4, THBS2, and PPARC1A were among the targets identified. Gene ontology (GO) terms enrichment analysis using the MSigDB showed that miRNAs associated with echocardiographic phenotype and prevalent HF have strong associations with genes involved in the extracellular matrix, biological adhesion, and tissue development and cellular differentiation (Figure 2).