The nodes identified included p53 signaling, transforming growth factor β (TGFβ) signaling, role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis, IL6 signaling, role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis, role of NFAT in regulation of the immune response, and mouse embryonic stem cell pluripotency (Figure 3, Supplementary Table 3). This evidence concerns the gene TP53 and rheumatoid arthritis.