While IgM does not bind to classical FcR, IgM has been reported to mediate phagocytosis via Fcα/μR (26) and complement receptor 3 (27), and the IgM receptor FcμR has been reported to be expressed on human activated macrophages and circulating monocytes (28), suggesting additional roles for IgM in immunity to malaria that should be investigated in future studies. The gene discussed is FCAMR; the disease is malaria.