Thus, even though I-CRP-induced cell death shares some biochemical features with apoptosis (Galluzzi et al., 2018), such as DNA degradation and mitochondrial damage (Martínez-Torres et al., 2018a), it induces caspase-independent cell death in NSCLC cell lines, as well as in HeLa cells. Here, CRP is linked to non-small cell lung carcinoma.