Among these DEGs, the upregulated expression of Plin2, Alox15, and Nr1i2, and the downregulated expression of Nr1d1 might correlate to hypothalamic disorders of lipid metabolism and contribute to hyperglycemia or insulin resistance in type 2 diabetic GK rats according to RGD annotations and previous studies. The gene discussed is NR1I2; the disease is Hyperglycemia.