BIRC5 and breast carcinoma: Consistently, our qRT-PCR analysis also showed that expression levels of BIRC5, E2F2, FOXM1 and MCM5 were significantly up-regulated in human breast cancer cell line MDA-MB-231 transfected with miR-10b antisense inhibitors and a trend of increase was also found for KIF2C expression, further validating the predicted target genes of miR-10b-5p in the current study.