Multiple assays including IgG, IgA, IgM, M-CSF, IL-6, CD4 and CD8 show the irregular dynamics at 2 days, 10 days and 20 days after fungal infection, particularly at 10 days , the potential causes might be the immune status of rabbits changed, whether in the attack group or in the control group. This evidence concerns the gene CD40LG and fungal infectious disease.