Multiple assays including IgG, IgA, IgM, M-CSF, IL-6, CD4 and CD8 show the irregular dynamics at 2 days, 10 days and 20 days after fungal infection, particularly at 10 days , the potential causes might be the immune status of rabbits changed, whether in the attack group or in the control group. The gene discussed is CD4; the disease is fungal infectious disease.