However, this must be taken with caution as Rivero et al. (2013) evaluated the expression of RGS4 and RGS10 proteins in postmortem brains of individuals with psychiatric disorders, and found unaltered membranes of RGS4 and cytosolic RGS10 proteins levels in schizophrenia and major depression in a mixed population from Switzerland and Spain (Rivero et al., 2013). This evidence concerns the gene RGS4 and major depressive disorder.