STAT3 and malignant colon neoplasm: Furthermore, STAT1 was also proved as the direct target of SARI in colon cancer cells, evidenced by Co‐IP and IF staining, as indicated in intestinal epithelial cells.18 Other transcriptional regulation factors of MCP‐1, including NF‐κB30, 31 and STAT3,32, 33 were up‐regulated in colon tissues of SARI−/− mice in CAC, but demonstrated not to be the direct target of SARI in colon cancer cells.