For example, knockout of IKKβ in intestinal mesenchymal cells (IMCs) impairs colitis‐associated tumorigenesis.22 Similarly, we showed that SARI deficiency promotes colitis‐associated tumorigenesis and causes higher mortality in mice, whereas no significant differences in tumour initiation and progression were found in colitis‐independent tumorigenesis model with SARIWT and SARI−/− mice. This evidence concerns the gene IKBKB and colitis.