By targeting TAGLN2,17 miR‐1 acted as a tumour suppressor in SCCHN.11 MiR‐99a was found to be down‐regulated in SCCHN, especially in SCC of oral cavity,18, 19, 20 subsequently contributing to the survival.21 In SCCHN, miR‐405 was found to inhibit tumour proliferation by targeting CDK6.22 Wang found miR‐203 could inhibit tumour growth and metastasis through PDPN.23 MiR‐15a was up‐regulated in HPV‐positive HSCC and might induce tumour apoptosis via BCL2L2 and BCL2.24, 25. This evidence concerns the gene BCL2L2 and head and neck squamous cell carcinoma.