Podoplanin immunoreactivity was significantly higher in the CVS cells of IUGR (group 7) and preeclampsia (group 8) tissues than in the third-trimester (group 3) control group (Fig. 2, group 7 versus group 3, p < 0.001; group 8 versus group 3, p < 0.001). The gene discussed is PDPN; the disease is fetal growth restriction.