LCN2 and acute kidney injury: There was a nonsignificant trend towards differential distribution of NGAL mRNA by severity of AKI (mild-to-moderate injury: median 2.1-fold increase (range 1–27.6); severe injury 1.4-fold increase (range 0.7–6.2); no injury 1.4-fold increase (range 0.8–8.2); p = 0.13 for a difference among groups) (Supplemental Figure S8).