This is consistent with previous work showing that CKI induced cytokines IL4 and IL10 in cancer patients with acute leukaemia24 and administration of CKI significantly increased the levels of IgA, IgG, IgM, IL2, IL4 and IL10, and decreased the levels of IL6 and TNF-α in rats with induced gastric cancer25. The gene discussed is CD40LG; the disease is cancer.