Gao and colleagues also reported that oxysophocarpine at 4 mg/ml had no effect, oxymatrine at 4 mg/ml (*P < 0.05) and CKI at 2 mg/ml (***P < 0.001) significantly reduced the proliferation of hepatocellular carcinoma SMMC-7721 cells in vitro6. The gene discussed is CHKA; the disease is hepatocellular carcinoma.