PTGES3 and colorectal carcinoma: Among the 11 genes in the signature, MMP12 (matrix metalloproteinase 12), PTGES3 (prostaglandin E synthase 3), and TERF2IP (telomeric repeat-binding factor 2-interacting protein 1) are involved in some clinical activities46, but their clinical association with CRC has been poorly reported, suggesting that these genes might be novel markers in CRC prognosis.