When comparing the expression levels of the genes between 11 CRC patients with disease recurrence and 8 CRC patients with no recurrence, three genes (i.e., EIF4A2, ITGB1, and RHOC) showed significant differences in expression between the recurrence subgroups and revealed positive correlations with the RNA-seq data in the AMC cohort (Supplementary Fig. S2a-c). This evidence concerns the gene ITGB1 and colorectal carcinoma.