ESR1 and viral infectious disease: Notably, all the other validated genes—ETS1 and IL-6 (miR-9-5p); MAX1, NCOA1, NR3C1, and ESR1 (miR-22-3p); and SDC4, PIK3CA, CAV1, and IQGAP1 (miR-124-3p)—belong to the connector class of hub genes, and presumably these connector hubs link multiple modules or communities in the PPI network to one another; thus, their expression in the cell after viral infection might find critical functional roles in JEV pathogenesis as well as maintenance of miRNA machinery.