Notably, all the other validated genes—ETS1 and IL-6 (miR-9-5p); MAX1, NCOA1, NR3C1, and ESR1 (miR-22-3p); and SDC4, PIK3CA, CAV1, and IQGAP1 (miR-124-3p)—belong to the connector class of hub genes, and presumably these connector hubs link multiple modules or communities in the PPI network to one another; thus, their expression in the cell after viral infection might find critical functional roles in JEV pathogenesis as well as maintenance of miRNA machinery. This evidence concerns the gene CAV1 and viral infectious disease.