Inhibition of adrenomedullin, a peptide involved in vasodilation, angiogenesis and vascular leakage, encoded by Adm gene, highly overexpressed in our study, was identified as a potential target of new therapies in diabetic retinopathy.18 On the other hand, an increased expression of Gfap gene might indicate reactive gliosis as a reaction to retinal impairment.19 This evidence concerns the gene ADM and diabetic retinopathy.