SPOP and cancer: However, further stratified analyses according to cancer type demonstrated the relationship between SPOP overexpression and LNM was positive in ccRCC (OR = 5.26; 95% CI: 1.66–16.68, P = .005, fixed-effect model) but negative in non-ccRCC (OR = 0.36; 95% CI: 0.21–0.62, P < .001, fixed-effect model) (Fig. 3B).