Additionally, the association between SPOP overexpression and LNM was positive in patients with clear cell renal cell carcinoma (ccRCC) (OR = 5.26; 95% CI: 1.66–16.68, P = .005) but negative in cancer patients without ccRCC (OR = 0.36; 95% CI: 0.21–0.62, P < .001). This evidence concerns the gene SPOP and nonpapillary renal cell carcinoma.