Patients with positive 5-HT antibodies showed increased serum neopterin and lysozyme, as well as plasma TNFα and IL-1; higher scores on the Hamilton Depression Rating Scale and the Fibromyalgia and Chronic Fatigue Syndrome Rating Scale; and more somatic symptoms including malaise and neurocognitive dysfunctions.[20]. Here, LYZ is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.